 | Scented cleaning products emit terpenes that react with indoor ozone to form 1–30 nm particles within minutes. Cleaning activities can generate particle concentrations exceeding outdoor levels, with particles capable of depositing deep in the lungs. Far-UV devices may intensify formation by producing ozone; fragrance-free products and ventilation can reduce exposure. |
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 | In six patients with treatment-refractory rheumatoid arthritis, CD19 CAR T-cell therapy markedly reduced disease activity; three achieved medication-free remission during up to 1 year of follow-up. Autoantibodies declined and B-cell reconstitution was predominantly naïve. Mild-to-moderate cytokine release syndrome occurred, while long-term efficacy and safety remain unknown. |
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 | A 17–19-year-old woman buried at Pień, Poland, c. 1620–1674, was interred with a sickle at her neck and a padlock on her toe, consistent with anti-demonic practices. Textile remains indicate high status, while isotopes suggest local childhood and low animal-protein intake. Grave disturbance and copper staining support postmortem ritual intervention. |
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 | In mouse models of chronic pain, alternate-day fasting reduced mechanical and heat sensitivity, improved cognitive performance, and reduced anxiety-like behavior. Effects were associated with improved intestinal barrier integrity, reduced neuroinflammation, increased Alistipes finegoldii, hippuric acid, and altered STING signaling; bacterial or metabolite supplementation reproduced benefits. |
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 | Among 31,044 U.S. adults aged ≥40 years, later first meals and very late last meals were associated with higher all-cause and cardiovascular mortality during 8.6 years of follow-up. Lowest risk occurred with a first meal at 7–8 a.m. and last meal at 7–8 p.m.; observational associations do not establish causality. |
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 | An eight-mRNA cocktail encoding cytokines and tumor-associated antigens reduced fibrosis, increased tumor necrosis, and produced complete responses in about half of pancreatic ductal adenocarcinoma mouse models. Responses persisted up to one year after treatment cessation, consistent with durable antitumor immune memory. |
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 | Engineered yeasts converted PET-derived compounds and agricultural biomass into proteins, fats, acids, vanilla flavoring and β-carotene. These ingredients were formulated into 3D-printed protein-rich cookies. Safety data supported edibility, while taste testing remains pending approval. |
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 | In pooled data from 91,339 participants, adherence ≥80% declined from 88% in year 1 to 79% by year 5. Higher adherence produced a 5.2-mmHg systolic blood pressure reduction and 11% fewer major cardiovascular events, versus 3.0 mmHg and no significant event reduction with lower adherence. |
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 | In >6,000 adults followed for 10 years, adding coronary artery calcium scores to PREVENT modestly improved overall cardiovascular risk discrimination (0.73 to 0.75). Scores most improved risk classification among adults with borderline or intermediate 10-year risk (3–9%), whereas routine scanning offered unclear benefit for low- or high-risk groups. |
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 | Analysis of 15 sperm samples identified 7,143 crossovers and 2,382 non-crossover gene-conversion events. A substantial fraction of non-crossover events appeared to arise during premeiotic mitotic divisions, with signatures resembling somatic DNA repair. Event frequency and location varied among individuals, including identical twins. |
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 | After myocardial infarction in mice, coronary collateral arteries formed predominantly through capillary arterialization rather than expansion of existing arteries. This process required VEGF-A–YY1–SETD1A–HES1 signaling, and selective loss of capillary-derived collaterals worsened scarring and cardiac dysfunction. Brief VEGF-A mRNA delivery increased functional collaterals in adult hearts. |
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 | Among 16,808 asymptomatic adults aged 18–70, imaging detected atherosclerotic plaques in 57.1%; prevalence was about 1 in 13 at ages 18–29 and 9 in 10 at ages 60–70. Men showed earlier plaque accumulation than women, while conventional risk scores identified only a small proportion of affected individuals. |
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 | Middle Jurassic katydid relatives produced diverse calls, including ~5 kHz pure tones and ultrasonic signals above 20 kHz. Wing-file morphology and models indicate that ultrasonic communication evolved before bats, likely aiding mate attraction, predator avoidance, and acoustic separation among coexisting species. |
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 | Self-contracting, vascularized skeletal-muscle grafts survived at least 81 days in mice and improved muscle mass, strength, endurance, bone density, metabolic measures, inflammation, and cognitive performance in aged or obese animals. Engineered grafts also normalized parathyroid hormone deficiency, supporting their potential as localized hormone-delivery platforms. |
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 | Bombus terrestris colonies exposed to the larval fungal pathogen Ascosphaera apis increasingly preferred quercetin-containing nectar, whereas colonies exposed to Serratia marcescens or unexposed controls did not. The behavior suggests pathogen-specific medicinal foraging, but effects on infection severity or larval survival were not measured. |
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 | An AI-guided search identified six viable low-power 3D-printing configurations for GRCop-42 copper–chromium–niobium alloy within 40 experiments, including printing at 500 W. The method prioritized promising and uncertain conditions from a search space exceeding 100 million options, potentially enabling use of commercial printers and reducing experimental costs. |
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 | Mapping 100 autism-risk genes identified >1,800 protein interactions, 87% previously unreported. Analysis of 54 mutations showed that diverse variants converge on shared protein complexes and can rewire interactions. FOXP1/FOXP2 variants disrupted FOXP1–FOXP4, altering cortical neuron development and excitability. |
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 | Himalayan cliff-bee honey can contain rhododendron-derived grayanotoxins that cause bradycardia, hypotension, dizziness and nausea, often within 30–60 minutes. Review of 68 cases found poisonings clustered during spring harvest and mainly involved deliberate consumption. Variable toxin concentrations make safe dosing unreliable, while global online sales may increase diagnostic and public-health risks. |
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 | CMB anisotropies constrain inhomogeneous first-order dark-sector phase transitions during the dark energy era. For transitions with β/H★ ≤ 25, less than 1% of dark energy could have been converted to other components. Models allowing a future contraction imply at least ~14 billion years before collapse for β/H★ ≤ 500. |
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 | Acetylene on oxygen-vacancy-forming CeO2 enabled graphene-based material synthesis at 300°C, far below conventional CVD temperatures. Temperature controlled product morphology: graphene quantum dots at 300°C, aggregated graphene at 450°C, and porous graphene at 600°C. The process may upgrade waste-derived carbon sources into functional materials. |
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